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Not to be confused with Diabetes insipidus.
Group of metabolic disorders involving long-term high blood sugar
Diabetes mellitus
Universal blue circle symbol for diabetes.[1]
Pronunciation
SpecialtyEndocrinology
SymptomsFrequent urination, increased thirst, increased hunger[2]
ComplicationsDiabetic ketoacidosis, hyperosmolar hyperglycemic state, heart disease, stroke, chronic kidney failure, foot ulcers, cognitive impairment, gastroparesis[2][3][4][5]
Risk factorsType 1: Family history[6]
Type 2: Obesity, lack of exercise, genetics[2][7]
Diagnostic methodHigh blood sugar[2]
TreatmentHealthy diet, physical exercise[2]
MedicationInsulin, anti-diabetic medication like metformin[2][8][9]
Frequency425 million (8.8%)[10]
Deaths3.2–5.0 million per year[10]

Diabetes mellitus (DM), commonly known as diabetes, is a group of metabolic disorders characterized by a high blood sugar level over a prolonged period of time.[11] Symptoms often include frequent urination, increased thirst, and increased appetite.[2] If left untreated, diabetes can cause many complications.[2] Acute complications can include diabetic ketoacidosis, hyperosmolar hyperglycemic state, or death.[3] Serious long-term complications include cardiovascular disease, stroke, chronic kidney disease, foot ulcers, damage to the nerves, damage to the eyes and cognitive impairment.[2][5]

Diabetes is due to either the pancreas not producing enough insulin, or the cells of the body not responding properly to the insulin produced.[12] There are three main types of diabetes mellitus:[2]

  • Type 1 diabetes results from the pancreas''s risk of early death.[2] In 2017, diabetes resulted in approximately 3.2 to 5.0 million deaths.[10] The global economic cost of diabetes related health expenditure in 2017 was estimated at US$727 billion.[10] In the United States, diabetes cost nearly US$245 billion in 2012.[22] Average medical expenditures among people with diabetes are about 2.3 times higher.[23]

    Contents

    Signs and symptoms[editreverses diabetes type 2 yo mama (🔥 eggs) | reverses diabetes type 2 diet plan printablehow to reverses diabetes type 2 for ]

    Overview of the most significant symptoms of diabetes

    The classic symptoms of untreated diabetes are unintended weight loss, polyuria (increased urination), polydipsia (increased thirst), and polyphagia (increased hunger).[24] Symptoms may develop rapidly (weeks or months) in type 1 diabetes, while they usually develop much the 1 last update 08 Jul 2020 more slowly and may be subtle or absent in type 2 diabetes.[25] The classic symptoms of untreated diabetes are unintended weight loss, polyuria (increased urination), polydipsia (increased thirst), and polyphagia (increased hunger).[24] Symptoms may develop rapidly (weeks or months) in type 1 diabetes, while they usually develop much more slowly and may be subtle or absent in type 2 diabetes.[25]

    Several other signs and symptoms can mark the onset of diabetes although they are not specific to the disease. In addition to the known ones above, they include blurred vision, headache, fatigue, slow healing of cuts, and itchy skin. Prolonged high blood glucose can cause glucose absorption in the lens of the eye, which leads to changes in its shape, resulting in vision changes. Long-term vision loss can also be caused by diabetic retinopathy. A number of skin rashes that can occur in diabetes are collectively known as diabetic dermadromes.[26]

    Diabetic emergencies[edit][edit]

    People (usually with type 1 diabetes) may also experience episodes of diabetic ketoacidosis (DKA), a metabolic disturbance characterized by nausea, vomiting and abdominal pain, the smell of acetone on the breath, deep breathing known as Kussmaul breathing, and in severe cases a decreased level of consciousness.[27] A rare but equally severe possibility is hyperosmolar hyperglycemic state (HHS), which is more common in type 2 diabetes and is mainly the result of dehydration.[27]

    Treatment-related low blood sugar (hypoglycemia) is common in people with type 1 and also type 2 diabetes depending on the medication being used. Most cases are mild and are not considered medical emergencies. Effects can range from feelings of unease, sweating, trembling, and increased appetite in mild cases to more serious effects such as confusion, changes in behavior such as aggressiveness, seizures, unconsciousness, and (rarely) permanent brain damage or death in severe cases.[28][29] Rapid breathing, sweating, and cold, pale skin are characteristic of low blood sugar but not definitive.[30] Mild to moderate cases are self-treated by eating or drinking something high in sugar. Severe cases can lead to unconsciousness and must be treated with intravenous glucose or injections with glucagon.[31]

    Complications the 1 last update 08 Jul 2020 [[edit the 1 last update 08 Jul 2020 ]]

    Retinopathy, nephropathy, and neuropathy are potential complications of diabetes

    All forms of diabetes increase the risk of long-term complications. These typically develop after many years (10–20) but may be the first symptom in those who have otherwise not received a diagnosis before that time.

    The major long-term complications relate to damage to blood vessels. Diabetes doubles the risk of cardiovascular disease[32] and about 75% of deaths in people with diabetes are due to coronary artery disease.[33] Other macrovascular diseases include stroke, and peripheral artery disease.

    reverses diabetes type 2 qualify for fmla (👍 cause hypertension) | reverses diabetes type 2 joint painhow to reverses diabetes type 2 for The primary complications of diabetes due to damage in small blood vessels include damage to the eyes, kidneys, and nerves.[34] Damage to the eyes, known as diabetic retinopathy, is caused by damage to the blood vessels in the retina of the eye, and can result in gradual vision loss and eventual blindness.[34] Diabetes also increases the risk of having glaucoma, cataracts, and other eye problems. It is recommended that people with diabetes visit an eye doctor once a year.[35] Damage to the kidneys, known as diabetic nephropathy, can lead to tissue scarring, urine protein loss, and eventually chronic kidney disease, sometimes requiring dialysis or kidney transplantation.[34] Damage to the nerves of the body, known as diabetic neuropathy, is the most common complication of diabetes.[34] The symptoms can include numbness, tingling, pain, and altered pain sensation, which can lead to damage to the skin. Diabetes-related foot problems (such as diabetic foot ulcers) may occur, and can be difficult to treat, occasionally requiring amputation. Additionally, proximal diabetic neuropathy causes painful muscle atrophy and weakness.

    There is a link between cognitive deficit and diabetes. Compared to those without diabetes, those with the disease have a 1.2 to 1.5-fold greater rate of decline in cognitive function.[36] Having diabetes, especially when on insulin, increases the risk of falls in older the 1 last update 08 Jul 2020 people.[37] There is a link between cognitive deficit and diabetes. Compared to those without diabetes, those with the disease have a 1.2 to 1.5-fold greater rate of decline in cognitive function.[36] Having diabetes, especially when on insulin, increases the risk of falls in older people.[37]

    Causesreverses diabetes type 2 menu (👍 remission) | reverses diabetes type 2 reddithow to reverses diabetes type 2 for [edit]

    Comparison of type 1 and 2 diabetes[19]
    Feature Type 1 diabetes Type 2 diabetes
    Onset Sudden Gradual
    Age at onset Mostly in children Mostly in adults
    Body size Thin or normal[38] Often obese
    Ketoacidosis Common Rare
    Autoantibodies Usually present Absent
    Endogenous insulin Low or absent Normal, decreased
    or increased
    Concordance
    in identical twins
    50% 90%
    Prevalence ~10% ~90%

    Diabetes mellitus is classified into four broad categories: type 1 diabetes, type 2 diabetes, gestational diabetes, and "".[12] The "" are a collection of a few dozen individual causes.[12] Diabetes is a more variable disease than once thought and people may have combinations of forms.[39] The term "", without qualification, refers to diabetes mellitus.[40]

    Type the 1 last update 08 Jul 2020 1Type 1reverses diabetes type 2 management (🔴 hands) | reverses diabetes type 2 risk factorshow to reverses diabetes type 2 for [edit]

    Main article: Type 1 diabetes

    reverses diabetes type 2 how do you get it (⭐️ pathophysiology) | reverses diabetes type 2 occurs whenhow to reverses diabetes type 2 for Type 1 diabetes is characterized by loss of the insulin-producing beta cells of the pancreatic islets, leading to insulin deficiency. This type can be further classified as immune-mediated or idiopathic. The majority of type 1 diabetes is of the immune-mediated nature, in which a T cell-mediated autoimmune attack leads to the loss of beta cells and thus insulin.[41] It causes approximately 10% of diabetes mellitus cases in North America and Europe. Most affected people are otherwise healthy and of a healthy weight when onset occurs. Sensitivity and responsiveness to insulin are usually normal, especially in the early stages. Although it has been called "" due to the frequent onset in children, the majority of individuals living with type 1 diabetes are now adults.[6]

    reverses diabetes type 2 januvia (🔴 treatment guidelines) | reverses diabetes type 2 childrenhow to reverses diabetes type 2 for "" diabetes, also known as unstable diabetes or labile diabetes, is a term that was traditionally used to describe the dramatic and recurrent swings in glucose levels, often occurring for no apparent reason in insulin-dependent diabetes. This term, however, has no biologic basis and should not be used.[42] Still, type 1 diabetes can be accompanied by irregular and unpredictable high blood sugar levels, and the potential for diabetic ketoacidosis or serious low blood sugar levels. Other complications include an impaired counterregulatory response to low blood sugar, infection, gastroparesis (which leads to erratic absorption of dietary carbohydrates), and endocrinopathies (e.g., Addison''s glucose production.[50]

    Type 2 diabetes is primarily due to lifestyle factors and genetics.[51] A number of lifestyle factors are known to be important to the development of type 2 diabetes, including obesity (defined by a body mass index of greater than 30), lack of physical activity, poor diet, stress, and urbanization.[19] Excess body fat is associated with 30% of cases in people of Chinese and Japanese descent, 60–80% of cases in those of European and African descent, and 100% of Pima Indians and Pacific Islanders.[12] Even those who are not obese may have a high waist–hip ratio.[12]

    Dietary factors such as sugar-sweetened drinks is associated with an increased risk.[52][53] The type of fats in the diet is also important, with saturated fat and trans fats increasing the risk and polyunsaturated and monounsaturated fat decreasing the risk.[51] Eating white rice excessively may increase the risk of diabetes, especially in Chinese and Japanese people.[54] Lack of physical activity may increase the risk of diabetes in some people.[55]

    Adverse childhood experiences (ACEs), including abuse, neglect, and household difficulties, increase the likelihood of type 2 diabetes later in life by 32%, with neglect having the strongest effect.[56]

    Gestational diabetes[edit]

    Main article: Gestational diabetes

    Gestational diabetes resembles type 2 diabetes in several respects, involving a combination of relatively inadequate insulin secretion and responsiveness. It occurs in about 2–10% of all pregnancies and may improve or disappear after delivery.[57] It is recommended that all pregnant women get tested starting around 24–28 weeks gestation.[58] It is most often diagnosed in the second or third trimester because of the increase in insulin-antagonist hormone levels that occurs at this time.[58] However, after pregnancy approximately 5–10% of women with gestational diabetes are found to have another form of diabetes, most commonly type 2.[57] Gestational diabetes is fully treatable, but requires careful medical supervision throughout the pregnancy. Management may include dietary changes, blood glucose monitoring, and in some cases, insulin may be required[59]

    Though it may be transient, untreated gestational diabetes can damage the health of the fetus or mother. Risks to the baby include macrosomia (high birth weight), congenital heart and central nervous system abnormalities, and skeletal muscle malformations. Increased levels of insulin in a fetus''s tissue receptors not responding to insulin (even when insulin levels are normal, which is what separates it from type 2 diabetes); this form is very uncommon. Genetic mutations (autosomal or mitochondrial) can lead to defects in beta cell function. Abnormal insulin action may also have been genetically determined in some cases. Any disease that causes extensive damage to the pancreas may lead to diabetes (for example, chronic pancreatitis and cystic fibrosis). Diseases associated with excessive secretion of insulin-antagonistic hormones can cause diabetes (which is typically resolved once the hormone excess is removed). Many drugs impair insulin secretion and some toxins damage pancreatic beta cells, whereas others increase insulin resistance (especially glucocorticoids which can provoke ""/wiki/Steroid_diabetes""Steroid diabetes""). The ICD-10 (1992) diagnostic entity, malnutrition-related diabetes mellitus (MRDM or MMDM, ICD-10 code E12), was deprecated by the World Health Organization (WHO) when the current taxonomy was introduced in 1999.[63]

    The following is a list of disorders that may increase the risk of diabetes:[64]

    the 1 last update 08 Jul 2020

    reverses diabetes type 2 prognosis (🔴 normal range chart) | reverses diabetes type 2 blood sugar levelshow to reverses diabetes type 2 for Pathophysiology[edit][edit]

    The fluctuation of blood sugar (red) and the sugar-lowering hormone insulin (blue) in humans during the course of a day with three meals. One of the effects of a sugar-rich vs a starch-rich meal is highlighted.
    Mechanism of insulin release in normal pancreatic beta cells. Insulin production is more or less constant within the beta cells. Its release is triggered by food, chiefly food containing absorbable glucose.

    Insulin is the principal hormone that regulates the uptake of glucose from the blood into most cells of the body, especially liver, adipose tissue and muscle, except smooth muscle, in which insulin acts via the IGF-1. Therefore, deficiency of insulin or the insensitivity of its receptors play a central role in all forms of diabetes mellitus.[66]

    The body obtains glucose from three main sources: the intestinal absorption of food; the breakdown of glycogen (glycogenolysis), the storage form of glucose found in the liver; and gluconeogenesis, the generation of glucose from non-carbohydrate substrates in the body.[67] Insulin plays a critical role in regulating glucose levels in the body. Insulin can inhibit the breakdown of glycogen or the process of gluconeogenesis, it can stimulate the transport of glucose into fat and muscle cells, and it can stimulate the storage of glucose in the form of glycogen.[67] The body obtains glucose from three main sources: the intestinal absorption of food; the breakdown of glycogen (glycogenolysis), the storage form of glucose found in the liver; and gluconeogenesis, the generation of glucose from non-carbohydrate substrates in the body.[67] Insulin plays a critical role in regulating glucose levels in the body. Insulin can inhibit the breakdown of glycogen or the process of gluconeogenesis, it can stimulate the transport of glucose into fat and muscle cells, and it can stimulate the storage of glucose in the form of glycogen.[67]

    Insulin is released into the blood by beta cells (β-cells), found in the islets of Langerhans in the pancreas, in response to rising levels of blood glucose, typically after eating. Insulin is used by about two-thirds of the body''s production of glucose.[97] Several other groups of drugs, mostly given by mouth, may also decrease blood sugar in type 2 diabetes. These include agents that increase insulin release (sulfonylureas), agents that decrease absorption of sugar from the intestines (acarbose), agents that inhibits dipeptidyl peptidase-4 (DPP-4) enzyme which inactivates incretins such as GLP-1 and GIP (Sitagliptin), agents that make the body more sensitive to insulin (Thiazolidinedione) and agents that increase the excretion of glucose in the urine (SGLT2 inhibitors).[97] When insulin is used in type 2 diabetes, a long-acting formulation is usually added initially, while continuing oral medications.[8] Doses of insulin are then increased to glucose targets.[8][98]

    reverses diabetes type 2 vegetarian diet (🔥 occur) | reverses diabetes type 2 diagnostic procedureshow to reverses diabetes type 2 for Blood pressure lowering[edit]

    Cardiovascular disease is a serious complication associated with diabetes, and many international guidelines recommend blood pressure treatment targets that are lower than 140/90 mmHg for people with diabetes.[99] However, there is only limited evidence regarding what the lower targets should be. A 2016 systematic review found potential harm to treating to targets lower than 140 mmHg,[100] and a subsequent systematic review in 2019 found no evidence of additional benefit from blood pressure lowering to between 130 - 140mmHg, although there was an increased risk of adverse events.[101]

    reverses diabetes type 2 permanently (☑ what is it) | reverses diabetes type 2 physiologyhow to reverses diabetes type 2 for 2015 American Diabetes Association recommendations are that people with diabetes and albuminuria should receive an inhibitor of the renin-angiotensin system to reduce the risks of progression to end-stage renal disease, cardiovascular events, and death.[102] There is some evidence that angiotensin converting enzyme inhibitors (ACEIs) are superior to other inhibitors of the renin-angiotensin system such as angiotensin receptor blockers (ARBs),[103] or aliskiren in preventing cardiovascular disease.[104] Although a more recent review found similar effects of ACEIs and ARBs on major cardiovascular and renal outcomes.[105] There is no evidence that combining ACEIs and ARBs provides additional benefits.[105]

    Aspirin[edit]

    reverses diabetes type 2 video (👍 naturally) | reverses diabetes type 2 snackshow to reverses diabetes type 2 for The use of aspirin to prevent cardiovascular disease in diabetes is controversial.[102] Aspirin is recommended in people at high risk of cardiovascular disease, however routine use of aspirin has not been found to improve outcomes in uncomplicated diabetes.[106] 2015 American Diabetes Association recommendations for aspirin use (based on expert consensus or clinical experience) are that low-dose aspirin use is reasonable in adults with diabetes who are at intermediate risk of cardiovascular disease (10-year cardiovascular disease risk, 5–10%).[102]

    Surgery the 1 last update 08 Jul 2020 [[edit]

    Weight loss surgery in those with obesity and type 2 diabetes is often an effective measure.[17] Many are able to maintain normal blood sugar levels with little or no medications following surgery[107] and long-term mortality is decreased.[108] There is, however, a short-term mortality risk of less than 1% from the surgery.[109] The body mass index cutoffs for when surgery is appropriate are not yet clear.[108] It is recommended that this option be considered in those who are unable to get both their weight and blood sugar under control.[110]

    A pancreas transplant is occasionally considered for people with type 1 diabetes who have severe complications of their disease, including end stage kidney disease requiring kidney transplantation.[111]

    Support[edit][edit]

    In countries using a general practitioner system, such as the United Kingdom, care may take place mainly outside hospitals, with hospital-based specialist care used only in case of complications, difficult blood sugar control, or research projects. In other circumstances, general practitioners and specialists share care in a team approach. Home telehealth support can be an effective management technique.[112]

    reverses diabetes type 2 quotes (👍 origin) | reverses diabetes type 2 neuropathy treatmenthow to reverses diabetes type 2 for Epidemiology[edit][edit]

    Rates of diabetes worldwide in 2014. The worldwide prevalence was 9.2%.
    Mortality rate of diabetes worldwide in 2012 per million inhabitants
      28–91
      92–114
      115–141
      142–163
      164–184
      185–209
      210–247
      248–309
      310–404
      405–1879

    In 2017, 425 million people had diabetes worldwide,[10] up from an estimated 382 million people in 2013[20] and from 108 million in 1980.[113] Accounting for the shifting age structure of the global population, the prevalence of diabetes is 8.8% among adults, nearly double the rate of 4.7% in 1980.[10][113] Type 2 makes up about 90% of the cases.[19][21] Some data indicate rates are roughly equal in women and men,[21] but male excess in diabetes has been found in many populations with higher type 2 incidence, possibly due to sex-related differences in insulin sensitivity, consequences of obesity and regional body fat deposition, and other contributing factors such as high blood pressure, tobacco smoking, and alcohol intake.[114][115]

    The WHO estimates that diabetes resulted in 1.5 million deaths in 2012, making it the 8th leading cause of death.[15][113] However another 2.2 million deaths worldwide were attributable to high blood glucose and the increased risks of cardiovascular disease and other associated complications (e.g. kidney failure), which often lead to premature death and are often listed as the underlying cause on death certificates rather than diabetes.[113][116] For example, in 2017, the International Diabetes Federation (IDF) estimated that diabetes resulted in 4.0 million deaths worldwide,[10] using modeling to estimate the total number of deaths that could be directly or indirectly attributed to diabetes.[10]

    Diabetes occurs throughout the world but is more common (especially type 2) in more developed countries. The greatest increase in rates has however been seen in low- and middle-income countries,[113] where more than 80% of diabetic deaths occur.[117] The fastest prevalence increase is expected to occur in Asia and Africa, where most people with diabetes will probably live in 2030.[118] The increase in rates in developing countries follows the trend of urbanization and lifestyle changes, including increasingly sedentary lifestyles, less physically demanding work and the global nutrition transition, marked by increased intake of foods that are high energy-dense but nutrient-poor (often high in sugar and saturated fats, sometimes referred to as the "" diet).[113][118] The global number of diabetes cases might increase by 48% between 2017 and 2045.[10]

    History[edit]

    Main article: History of diabetes

    Diabetes was one of the first diseases described,[119] with an Egyptian manuscript from c. 1500 BCE mentioning ""[120] The Ebers papyrus includes a recommendation for a drink to take in such cases.[121] The first described cases are believed to have been type 1 diabetes.[120] Indian physicians around the same time identified the disease and classified it as madhumeha or "", noting the urine would attract ants.[120][121]

    The term "" or "" was first used in 230 BCE by the Greek Apollonius of Memphis.[120] The disease was considered rare during the time of the Roman empire, with Galen commenting he had only seen two cases during his career.[120] This is possibly due to for 1 last update 08 Jul 2020 the diet and lifestyle of the ancients, or because the clinical symptoms were observed during the advanced stage of the disease. Galen named the disease "" (diarrhea urinosa).[122] The term "" or "" was first used in 230 BCE by the Greek Apollonius of Memphis.[120] The disease was considered rare during the time of the Roman empire, with Galen commenting he had only seen two cases during his career.[120] This is possibly due to the diet and lifestyle of the ancients, or because the clinical symptoms were observed during the advanced stage of the disease. Galen named the disease "" (diarrhea urinosa).[122]

    The earliest surviving work with a detailed reference to diabetes is that of Aretaeus of Cappadocia (2nd or early 3rdreverses diabetes type 2 genetic (☑ video) | reverses diabetes type 2 untreatedhow to reverses diabetes type 2 for  century CE). He described the symptoms and the course of the disease, which he attributed to the moisture and coldness, reflecting the beliefs of the ""/wiki/Pneumatic_school""Pneumatic school"". He hypothesized a correlation between diabetes and other diseases, and he discussed differential diagnosis from the snakebite, which also provokes excessive thirst. His work remained unknown in the West until 1552, when the first Latin edition was published in Venice.[122]

    Two types of diabetes were identified as separate conditions for the first time by the Indian physicians Sushruta and Charaka in 400–500 CE with one type being associated with youth and another type with being overweight.[120] The term "" or "" was added by the Briton John Rolle in the late 1700s to separate the condition from diabetes insipidus, which is also associated with frequent urination.[120] Effective treatment was not developed until the early part of the 20th century when Canadians Frederick Banting and Charles Herbert Best isolated and purified insulin in 1921 and 1922.[120] This was followed by the development of the long-acting insulin NPH in the 1940s.[120]

    reverses diabetes type 2 patch (🔥 lecture) | reverses diabetes type 2 onset agehow to reverses diabetes type 2 for Etymology[edit]

    reverses diabetes type 2 natural remedies (☑ metformin) | reverses diabetes type 2 mayo clinichow to reverses diabetes type 2 for The word diabetes (/ˌd the 1 last update 08 Jul 2020 ..əˈ the 1 last update 08 Jul 2020 bb the 1 last update 08 Jul 2020 ttz/ or / for 1 last update 08 Jul 2020 ˌˌd.ə the for 1 last update 08 Jul 2020 1 last update 08 Jul 2020 ˈˈbtɪs// for 1 last update 08 Jul 2020 ˌˌd.ə the 1 last update 08 Jul 2020 ˈˈbtɪs/) comes from Latin diabētēs, which in turn comes from Ancient Greek διαβήτης (diabētēs), which literally means ""/wiki/Siphon""Siphon"".[123] Ancient Greek physician Aretaeus of Cappadocia (fl. 1st century CE) used that word, with the intended meaning "", as the name for the disease.[124][125] Ultimately, the word comes from Greek διαβαίνειν (diabainein), meaning ""[123] which is composed of δια- (dia-), meaning "" and βαίνειν (bainein), meaning "".[124] The word "" is first recorded in English, in the form diabete, in a medical text written around 1425.

    The word mellitus (reverses diabetes type 2 episode (⭐️ drugs) | reverses diabetes type 2 immune systemhow to reverses diabetes type 2 for /reverses diabetes type 2 etiology (🔥 in us) | reverses diabetes type 2 health promotionhow to reverses diabetes type 2 for məˈltəs/ or /ˈmɛlɪtəs//ˈmɛlɪtəs/) comes from the classical Latin word mellītus, meaning ""[126] (i.e. sweetened with honey;[126] honey-sweet[127]). The Latin word comes from mell-, which comes from mel, meaning "";[126][127] sweetness;[127] pleasant thing,[127] and the suffix -ītus,[126] whose meaning is the same as that of the English suffix "".[128] It was Thomas Willis who in 1675 added "" to the word "" as a designation for the disease, when he noticed the urine of a person with diabetes had a sweet taste (glycosuria). This sweet taste had been noticed in urine by the ancient Greeks, Chinese, Egyptians, Indians, and Persians.

    Society and for 1 last update 08 Jul 2020 cultureSociety and culture[edit the 1 last update 08 Jul 2020 ]]

    The 1989 ""/wiki/St._Vincent_Declaration""St. Vincent Declaration""[129][130] was the result of international efforts to improve the care accorded to those with diabetes. Doing so is important not only in terms of quality of life and life expectancy but also economically – expenses due to diabetes have been shown to be a major drain on health – and productivity-related resources for healthcare systems and governments.

    Several countries established more and less successful national diabetes programmes to improve treatment of the disease.[131]

    People with diabetes who have neuropathic symptoms such as numbness or tingling in feet or hands are twice as likely to be unemployed as those without the symptoms.[132]

    In 2010, diabetes-related emergency room (ER) visit rates in the United States were higher among people from the lowest income communities (526 per 10,000 population) than from the highest income communities (236 per 10,000 population). Approximately 9.4% of diabetes-related ER visits were for the uninsured.[133]

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    The term "" has replaced several former terms, including childhood-onset diabetes, juvenile diabetes, and insulin-dependent diabetes mellitus (IDDM). Likewise, the term "" has replaced several former terms, including adult-onset diabetes, obesity-related diabetes, and noninsulin-dependent diabetes mellitus (NIDDM). Beyond these two types, there is no agreed-upon standard nomenclature.[reverses diabetes type 2 with fasting (☑ your guide to getting started) | reverses diabetes type 2 veteranhow to reverses diabetes type 2 for citation needed]

    Diabetes mellitus is also occasionally known as "" to differentiate it from diabetes insipidus.[134]

    Other animals[edit]

    In animals, diabetes is most commonly encountered in dogs and cats. Middle-aged animals are most commonly affected. Female dogs are twice as likely to be affected as males, while according to some sources, male cats are more prone than females. In both species, all breeds may be affected, but some small dog breeds are particularly likely to develop diabetes, such as Miniature Poodles.[135]

    Feline diabetes is strikingly similar to human type 2 diabetes. The Burmese breed, along with the Russian Blue, Abyssinian, and Norwegian Forest cat breeds, showed an increased risk of DM than other breeds. There is an association between overweight and an increased risk of feline diabetes.[136]

    The symptoms may relate to fluid loss and polyuria, but the course may also be insidious. Diabetic animals are the 1 last update 08 Jul 2020 more prone to infections. The long-term complications recognized in humans are much rarer in animals. The principles of treatment (weight loss, oral antidiabetics, subcutaneous insulin) and management of emergencies (e.g. ketoacidosis) are similar to those in humans.[135] The symptoms may relate to fluid loss and polyuria, but the course may also be insidious. Diabetic animals are more prone to infections. The long-term complications recognized in humans are much rarer in animals. The principles of treatment (weight loss, oral antidiabetics, subcutaneous insulin) and management of emergencies (e.g. ketoacidosis) are similar to those in humans.[135]

    Research[edit]

    Inhalable insulin has been developed.[citation needed] The original products were withdrawn due to side effects.[citation needed] Afrezza, under development by the pharmaceuticals company MannKind Corporation, was approved by the United States Food and Drug Administration (FDA) for general sale in June 2014.[137] An advantage to inhaled insulin is that it may be more convenient and easy to use.[138]

    Transdermal insulin in the form of a cream has been developed and trials are being conducted on people with type 2 diabetes.[139][140]

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    The Diabetes Control and Complications Trial (DCCT) was a clinical study conducted by the United States National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) that was published in the New England Journal of Medicine in 1993. Test subjects all had type 1 diabetes and were randomized to a tight glycemic arm and a control arm with the standard of care at the time; people were followed for an average of seven years, and people in the treatment had dramatically lower rates of diabetic complications. It was as a landmark study at the time, and significantly changed the management of all forms of diabetes.[96][141][142]

    The United Kingdom Prospective Diabetes Study (UKPDS) was a clinical study conducted by Z that was published in The Lancet in 1998. Around 3,800 people with type 2 diabetes were followed for an average of ten years, and were treated with tight glucose control or the standard of care, and again the treatment arm had far better outcomes. This confirmed the importance of tight glucose control, as well as blood pressure control, for people with this condition.[96][143][144]

    References[edit]

    1. ^ "". International Diabetes Federation. 17 March 2006. Archived from the original on 5 August 2007."". International Diabetes Federation. 17 March 2006. Archived from the original on 5 August 2007.
    2. ^ a b c d e f g h i j k l m n o p q r s t u v w x "". WHO. October 2013. Archived from the original on 26 August 2013. Retrieved 25 March 2014.
    3. ^ a b Kitabchi AE, Umpierrez GE, Miles JM, Fisher JN (July 2009). "". Diabetes Care. 32 (7): 1335–43. doi:10.2337/dc09-9032. PMC 2699725. PMID 19564476.Kitabchi AE, Umpierrez GE, Miles JM, Fisher JN (July 2009). "". Diabetes Care. 32 (7): 1335–43. doi:10.2337/dc09-9032. PMC 2699725. PMID 19564476.
    4. ^ Krishnasamy S, Abell TL (July 2018). "". Diabetes Therapy. 9 (Suppl 1): 1–42. doi:10.1007/s13300-018-0454-9. PMC 6028327. PMID 29934758.
    5. reverses diabetes type 2 symptoms women (🔥 natural cures treatments) | reverses diabetes type 2 episodehow to reverses diabetes type 2 for ^ a b Saedi, E; Gheini, MR; Faiz, F; Arami, MA (15 September 2016). "". World Journal of Diabetes. 7 (17): 412–22. doi:10.4239/wjd.v7.i17.412. PMC 50270055027005. PMID 27660698.reverses diabetes type 2 ketosis (👍 mellitus nature journal) | reverses diabetes type 2 mellitus naturehow to reverses diabetes type 2 for
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    External links[edit for 1 last update 08 Jul 2020 ]]

    Classification
    External resources
    Diabetes mellitusat Wikipedia''s Standards of Medical Care in Diabetes 2019
  • Polonsky KS (October 2012). "". The New England Journal of Medicine. 367 (14): 1332–40. doi:10.1056/NEJMra1110560. PMID 23034021.
Diseases of the endocrine system (E00–E35, 240–259)
Pancreas/
glucose
metabolism
Hypofunction
Hyperfunction
Hypothalamic/
pituitary axes
Hypothalamus
Pituitary
Hyperpituitarism
Thyroid
Hypothyroidism
Hyperthyroidism
Goitre
Parathyroid
Hypoparathyroidism
Hyperparathyroidism
Adrenal
Hyperfunction
Gonads
Height
Multiple
Types
Blood tests
Management
Complications
Other
Authority control
  • GND: 4070446-4
  • LCCN: reverses diabetes type 2 mayo clinic (👍 genetic link) | reverses diabetes type 2 occurs whenhow to reverses diabetes type 2 for sh85037456
  • NDL: reverses diabetes type 2 explained (🔴 quotes) | reverses diabetes type 2 treatment algorithmhow to reverses diabetes type 2 for 00573283
  • NSK: 000226166
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